Connect to SAP Gateway failed. Partner not reached

Hi,

After creating a new system in System Landscape Directory, I am trying to maintain that system alias under Universal Worklist Configuration.

However, I am getting the following error while trying to re-register the UWL system alias:-

"Could not get connection for alias: Contact your System administrator".

Also, in the nwa error log, the below error is generated in developer traces:-

RFC_ERROR_COMMUNICATION: Connect to SAP Gateway failed

ERROR:           partner '<oIP >:sapgw01' not reached

ERRNO TEXT   WSAECONNREFUSED: Connection Refused

Can anyone tell me how to solve this..

Thanks